Arsenic Induced Vascular Endothelial Dysfunction Prevented by Antioxidants in Fetal kidneys of Albino Mice

Background &Objectives: Cardiovascular diseases and hypertension has a significant correlation with chronic arsenic exposure through drinking water. This study was designed to investigate the prevention of sodium arsenate induced vascular disorders by Vitamins C& E in fetal renal blood vessels albino mice.
 Materials & Methods: Gravid mice BALB/c strain (twenty four) were randomly divided into 4 groups having 6 animals each. Control group A inoculated 0.1ml/kg/day distilled water I/P for 18 days. Animals B, C D given single injection 35mg/kg on 8th GD, whereas also injected Vitamin C, 9 mg/kg/day vitamin 15 route, beginning from GD continued entire pregnancy period. On 18th day gestation kidneys extracted. Histological examination performed any discernable congestion, endothelial disruption hyalinization frequency changes expressed as percentages.
 Results: In (B) induction resulted congestion vessels, hemorrhages glomerular capillaries thickening walls. The addition respectively had reduced thickening. Mean score histological statistically significant.
 Conclusions: results showed antioxidant prospective combating against lesions arsenate.